Pair Name	Cepharanthine, S-1
Disease Info	[ICD-11: 2B66.0]	Oral squamous cell carcinoma		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Down-regulation	Expression	DPYD	hsa1806
	Down-regulation	Expression	TYMS	hsa7298
In Vitro Model	HSC-2	Oral cavity squamous cell carcinoma	Homo sapiens (Human)	CVCL_1287
	B88	B88 cells were isolated from an OSCC patient	/	N.A.
In Vivo Model	B88 or HSC2 cells (1×10⁶) were suspended in 0.1 mL of serum-free medium and injected into the subcutaneous tissue of 5-week-old nude mice.
Result	Combined therapy of cepharanthine and S-1 exerted antitumor effects on human OSCC xenografts markedly and significantly induced apoptotic cells in tumors treated with cepharanthine plus S-1.